Small molecule inhibitors of the CXXC domain, an epigenetic reader of DNA methylation

The CXXC domain functions as a reader of DNA methylation, binding to non-methylated CpGs. We will develop small molecule inhibitors and test effects on DNA methylation and growth of leukemia cells.

John H. Bushweller
School of Medicine

Steven Richard Caliari
School of Engineering and Applied Science

Francine Evalina Garrett-Bakelman
School of Medicine

Find out more: https://3c.virginia.edu/projects/52
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